FBXO8
LOCUS ID26269
GENE_SYMBOLFBXO8
GENE NAMEF-box protein 8
SYNONYMNSFBS, DC10, FBX8
CHROMOSOME4
HOMOLOGENE ID8137
microRNAsNANA
GENE SUMMARY
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitition. The F-box proteins are divided into 3 classesFbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It contains a C-termil amino acid sequence that bears a significant similarity with a portion of yeast Sec7p, a critical regulator of vesicular protein transport. This human protein may interact with ADP-ribosylation factor(s)(ARFs) and exhibit ARF-GEF (guanine nucleotide exchange factor) activity. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Retinopathy1. It was concluded that thecombination of HbA1 and FBS levels will be useful for long-term control of diabetes and of progression of retinopathy.6855017