FFAR1
LOCUS ID2864
GENE_SYMBOLFFAR1
GENE NAMEfree fatty acid receptor 1
SYNONYMNSFFA1R, GPR40, GPCR40
CHROMOSOME19
HOMOLOGENE ID3876
microRNAsNANA
GENE SUMMARY
This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for medium and long chain free fatty acids and may be involved in the metabolic regulation of insulin secretion. Polymorphisms in this gene may be associated with type 2 diabetes. [provided by RefSeq, Apr 2009]

OBSERVATIONS

Complication Evidence PMID
Retinopathy1. Furthermore, in response to conjugated linoleic acids or trans isomers of arachidonic acid, GPR40 was recently demonstrated in rodents to mediate lipotoxicity to beta-cells, neurons, or microvessels, which in diabetes, retinopathy, stroke, etc.25615413