FGF21
LOCUS ID26291
GENE_SYMBOLFGF21
GENE NAMEfibroblast growth factor 21
SYNONYMNSNONE
CHROMOSOME19
HOMOLOGENE ID10428
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Elevated serum FGF21 levels may be a useful biomarker for predicting kidney disease progression especially in early stages of diabetic nephropathy. 2. Our suggest that FGF21 improves insulin resistance and protects against renal injury through both improvement of systemic metabolic alterations and antifibrotic effects in type 2 diabetic nephropathy.25625802 , 21176857
Cardiovascular1. Higher baseline plasma FGF21 levels were associated with higher risk of cardiovascular events in patients with type 2 diabetes.25425220
Retinopathy1. Higher baseline FGF21 levels are seen in patients with type 2 diabetes and established microvascular disease, and predict the future development of new microvascular disease.26055067
Atherosclerosis1. In humans, circulating FGF21 levels are elevated in corory heart disease and atherosclerosis, and are associated with a higher risk of cardiovascular events in patients with type 2 diabetes.26379627