FGF23
LOCUS ID8074
GENE_SYMBOLFGF23
GENE NAMEfibroblast growth factor 23
SYNONYMNSADHR, FGFN, HYPF, HPDR2, PHPTC
CHROMOSOME12
HOMOLOGENE ID10771
microRNAsNANA
GENE SUMMARY
This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC). [provided by RefSeq, Feb 2013]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. There were no differences in serum osteoprotegerin and vascular calcification among patients with different stages of diabetic nephropathy, but serum FGF23 levels were elevated in those with stage 4 diabetic nephropathy.23302066
Cardiovascular1. Additionally, high FGF23 levels have been a significant predictor of cardiovascular mortality and morbidity in chronic kidney disease and HD patients.26030798
Atherosclerosis1. Higher FGF23 associated with greater likelihood and burden of carotid atherosclerosis independent of CKD.26112008