| FGF23 |
| LOCUS ID | 8074 | |||||||||||||||||||
| GENE_SYMBOL | FGF23 | |||||||||||||||||||
| GENE NAME | fibroblast growth fa | |||||||||||||||||||
| SYNONYMNS | ADHR, FGFN, HYPF, HPDR2, PHPTC | |||||||||||||||||||
| CHROMOSOME | 12 | |||||||||||||||||||
| HOMOLOGENE ID | 10771 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene a |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. There were no differences in serum osteoprotegerin and vascular calcification among patients with different stages of diabetic nephropathy, but serum FGF23 levels were elevated in those with stage 4 diabetic nephropathy. | 23302066 |
| Cardiovascular | 1. Additionally, high FGF23 levels have been a significant predictor of cardiovascular mortality and morbidity in chronic kidney disease and HD patients. | 26030798 |
| Atherosclerosis | 1. Higher FGF23 associated with greater likelihood and burden of carotid atherosclerosis independent of CKD. | 26112008 |
| Insulin resistance and Inflammation | 1. FGF23 was positively associated with IL-6, hsCRP, IL-10, HOMA-IR, BMI and WC in individuals without CKD (chronic kidney disease), but not among individuals with CKD. Additionally, FGF23 was positively associated with resistin irrespective of CKD status. | 25811862 |