| FGFR1 |
| LOCUS ID | 2260 | ||||||||||
| GENE_SYMBOL | FGFR1 | ||||||||||
| GENE NAME | fibroblast growth fa | ||||||||||
| SYNONYMNS | CEK, FLG, HH2, OGD, ECCL, FLT2, KAL2, BFGFR, CD331, FGFBR, FLT-2, HBGFR, N-SAM, FGFR-1, | ||||||||||
| CHROMOSOME | 8 | ||||||||||
| HOMOLOGENE ID | 69065 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The e |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Atherosclerosis | 1. Endogenous expression of FGF-21 and its receptor FGFR1 were upregulated in apoE(-/-) mice, and exogenous administration of FGF-21 ameliorated the atherogenic-induced dyslipidemia and vascular atherosclerotic lesions. | 25092223 |