| FKBP10 |
| LOCUS ID | 60681 | ||||||||||
| GENE_SYMBOL | FKBP10 | ||||||||||
| GENE NAME | FK506 binding protei | ||||||||||
| SYNONYMNS | OI6, OI11, BRKS1, FKBP65, PPIASE, hFKBP65 | ||||||||||
| CHROMOSOME | 17 | ||||||||||
| HOMOLOGENE ID | 7718 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl citrans isomerase (PPIase) family. This protein localizes to the endoplasmic reticulum and acts as a molecular chaperone. Altertively spliced variants encoding different isoforms have been reported, but their biological validity has not been determined.[provided by RefSeq, Nov 2009] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Cardiovascular | 1. Many individual genes within the PPIase family are associated with several age-related diseases including cardiovascular diseases (CVDs), atherosclerosis, type II diabetes (T2D), chronic kidney disease (CDK), neurodegeneration, cancer and age-related macular degeneration (AMD), in addition to the ageing process itself. | 25986561 |