| FKBP2 |
| LOCUS ID | 2286 | ||||||||||
| GENE_SYMBOL | FKBP2 | ||||||||||
| GENE NAME | FK506 binding protei | ||||||||||
| SYNONYMNS | PPIase, FKBP-13 | ||||||||||
| CHROMOSOME | 11 | ||||||||||
| HOMOLOGENE ID | 40604 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is thought to function as an ER chaperone and may also act as a component of membrane cytoskeletal scaffolds. Multiple altertively spliced variants, encoding the same protein, have been identified. |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Atherosclerosis | 1. Many individual genes within the PPIase family are associated with several age-related diseases including cardiovascular diseases (CVDs), atherosclerosis, type II diabetes (T2D), chronic kidney disease (CDK), neurodegeneration, cancer and age-related macular degeneration (AMD), in addition to the ageing process itself. | 25986561 |