FKBP4
LOCUS ID2288
GENE_SYMBOLFKBP4
GENE NAMEFK506 binding protei
SYNONYMNSHBI, p52, Hsp56, FKBP51, FKBP52, FKBP59, PPIase
CHROMOSOME12
HOMOLOGENE ID36085
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interact

OBSERVATIONS

Complication Evidence PMID
Cardiovascular1. Many individual genes within the PPIase family are associated with several age-related diseases including cardiovascular diseases (CVDs), atherosclerosis, type II diabetes (T2D), chronic kidney disease (CDK), neurodegeneration, cancer and age-related macular degeneration (AMD), in addition to the ageing process itself.25986561