| FMO3 |
| LOCUS ID | 2328 | ||||||||||
| GENE_SYMBOL | FMO3 | ||||||||||
| GENE NAME | flavin containing mo | ||||||||||
| SYNONYMNS | TMAU, FMOII, dJ127D3.1 | ||||||||||
| CHROMOSOME | 1 | ||||||||||
| HOMOLOGENE ID | 128199 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| Flavin-containing monooxygeses (FMO) are an important class of drug-metabolizing enzymes that catalyze the DPH-dependent oxygetion of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expresse |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Atherosclerosis | 1. Knockdown of FMO3 in insulin-resistant mice suppresses FoxO1, a central node for metabolic control, and entirely prevents the development of hyperglycaemia, hyperlipidemia and atherosclerosis. | 25849138 |