FNDC5
LOCUS ID252995
GENE_SYMBOLFNDC5
GENE NAMEfibronectin type III domain containing 5
SYNONYMNSFRCP2, irisin
CHROMOSOME1
HOMOLOGENE ID17812
microRNAsNANA
GENE SUMMARY
This gene encodes a secreted protein that is released from muscle cells during exercise. The encoded protein may participate in the development of brown fat. Translation of the precursor protein initiates at a non-AUG start codon at a position that is conserved as an AUG start codon in other organisms. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. There is an association of FNDC5 rs16835198 G>T polymorphism with T2DM, diabetic nephropathy and irisin levels; FNDC5 rs16835198 TT genotype associates with decreased risk of T2DM in Egyptians with no effect on renal complications28479383