FOXO4
LOCUS ID4303
GENE_SYMBOLFOXO4
GENE NAMEforkhead box O4
SYNONYMNSAFX, AFX1, MLLT7
CHROMOSOMEX
HOMOLOGENE ID4342
microRNAsNANA
GENE SUMMARY
This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a D binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. siRNA for FOXO4 abolished AGE-BSA-induced apoptosis of podocytes. Our study suggests that an AGE-RAGE interaction contributes to podocyte apoptosis by activation of the FOXO4 transcription factor.17667983