| FOXO4 |
| LOCUS ID | 4303 | ||||||||||
| GENE_SYMBOL | FOXO4 | ||||||||||
| GENE NAME | forkhead box O4 | ||||||||||
| SYNONYMNS | AFX, AFX1, MLLT7 | ||||||||||
| CHROMOSOME | X | ||||||||||
| HOMOLOGENE ID | 4342 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a D binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found fo |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. siRNA for FOXO4 abolished AGE-BSA-induced apoptosis of podocytes. Our study suggests that an AGE-RAGE interaction contributes to podocyte apoptosis by activation of the FOXO4 transcription factor. | 17667983 |