GAP43
LOCUS ID2596
GENE_SYMBOLGAP43
GENE NAMEgrowth associated protein 43
SYNONYMNSB-50, PP46
CHROMOSOME3
HOMOLOGENE ID1545
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axol regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Altertively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Neuropathy1. Our present findings are in accordance with these observations and extent previous findings by demonstrating a markedly decreased expression of Nf68 and GAP43 in sciatic nerve of hyperglycemic ob/ob compared with normoglycemic ob/+ mice.22412941