GDF15
LOCUS ID9518
GENE_SYMBOLGDF15
GENE NAMEgrowth differentiation factor 15
SYNONYMNSPDF, MIC1, PLAB, MIC-1, G-1, PTGFB, GDF-15
CHROMOSOME19
HOMOLOGENE ID3576
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene belongs to the transforming growth factor-beta (TGF-beta) family. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress reponse program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. [provided by RefSeq, Sep 2015]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. GDF15 protects the renal interstitium and tubular compartment in experimental type 1 and 2 diabetes without affecting glomerular damage.23986522
Cardiovascular1. the level of GDF15 may be a useful predictive biomarker of cardiovascular risk in newly diagnosed T2D patients.27510384