| GFPT2 |
| LOCUS ID | 9945 | ||||||||||
| GENE_SYMBOL | GFPT2 | ||||||||||
| GENE NAME | glutamine-fructose-6 | ||||||||||
| SYNONYMNS | GFAT2 | ||||||||||
| CHROMOSOME | 5 | ||||||||||
| HOMOLOGENE ID | 68439 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| GFPT2 (Glutamine-Fructose-6-Phosphate Transaminase 2) is a Protein Coding gene. Among its related pathways are?Alanine, aspartate and glutamate metabolism?and?Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include?carbohydrate binding?and?glutamine-fructose-6-phosphate transaminase (isomerizing) activity. An important paralog of this gene is?GFPT1. |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. Several variants in the 3' untranslated region (UTR) and exon 18 were also associated with T2DM in Caucasian individuals (P < 0.05), and the SNP in the 3' UTR was associated with diabetic nephropathy in African-American subjects (P = 0.047). GFPT2 mRNA levels in transformed lymphocytes from study subjects were significantly increased among African-American subjects compared with Caucasian individuals, regardless of diagnosis. | 14764791 |