GGT2
LOCUS ID728441
GENE_SYMBOLGGT2
GENE NAMEgamma-glutamyltransferase 2
SYNONYMNSGGT, GGT, 2
CHROMOSOME22
HOMOLOGENE ID68450
microRNAsNANA
GENE SUMMARY
GGT2 belongs to the gamma-glutamyltransferase (GGT; EC 2.3.2.2) gene family. GGT is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. GGT is also key to glutathione homeostasis because it provides substrates for glutathione synthesis (Heisterkamp et al., 2008 [PubMed 18357469]).[supplied by OMIM, Oct 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Urinary GGT and ALP have potential value in the diagnosis of nephropathy in type 2 diabetic patients, but GGT has a slightly higher ability to discrimite nephropathy than ALP.21527256