| GK |
| LOCUS ID | 2710 | ||||||||||
| GENE_SYMBOL | GK | ||||||||||
| GENE NAME | glycerol kinase | ||||||||||
| SYNONYMNS | GK1, GKD | ||||||||||
| CHROMOSOME | X | ||||||||||
| HOMOLOGENE ID | 21848 |
| microRNAs | miR-51 | 27495223 |
| GENE SUMMARY |
|---|
| The protein encoded by this gene belongs to the FGGY kinase family. This protein is a key enzyme in the regulation of glycerol uptake and metabolism. It catalyzes the phosphorylation of glycerol by ATP, yielding ADP and glycerol-3-phosphate. Mutations in this gene are associated with glycerol kinase deficiency (GKD). Altertively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Cardiovascular | 1. Recent evidence suggests that genetic variation at the CALPN10, FABP4, GK, GST, PPARA, and PPARG loci may confer higher cardiovascular disease risk in patients with type 2 diabetes mellitus. | 18241614 |