| GLO1 |
| LOCUS ID | 2739 | ||||||||||||||||
| GENE_SYMBOL | GLO1 | ||||||||||||||||
| GENE NAME | glyoxalase I | ||||||||||||||||
| SYNONYMNS | GLYI, GLOD1, HEL-S-74 | ||||||||||||||||
| CHROMOSOME | 6 | ||||||||||||||||
| HOMOLOGENE ID | 4880 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. Glyoxalase I is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere. [provided by RefSeq, Jul 2008] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. GLO1 C-7T polymorphism alters promoter activity and confers susceptibility to nephropathy and retinopathy to Type 2 diabetic patients. | 21738003 |
| Atherosclerosis | 1. The GLO1 C-7T polymorphism is associated with carotid atherosclerosis in Chinese patients with type 2 diabetes. | 21294693 |
| Neuropathy | 1. Diabetic BALB/cJ mice with reduced GLO1 levels showed increased mechanical thresholds indicative of the development of insensate neuropathy, loss of epidermal fibers, and reduced amounts of components of mitochondrial oxidative phosphorylation proteins including Complex I and V. | 22500508 |