| GNB3 |
| LOCUS ID | 2784 | ||||||||||
| GENE_SYMBOL | GNB3 | ||||||||||
| GENE NAME | guanine nucleotide b | ||||||||||
| SYNONYMNS | NA | ||||||||||
| CHROMOSOME | 12 | ||||||||||
| HOMOLOGENE ID | 55628 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukas |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. The study provided evidence against the major impact of the GNB3 C825T polymorphism on the increased risk of the development of nephropathy or hypertension in type 2 diabetic patients. | 10970984 |