| GSTM1 |
| LOCUS ID | 2944 | ||||||||||||||||
| GENE_SYMBOL | GSTM1 | ||||||||||||||||
| GENE NAME | glutathione S-transf | ||||||||||||||||
| SYNONYMNS | MU, H-B, GST1, GTH4, GTM1, MU-1, GSTM1-1, GSTM1a-1a, GSTM1 | ||||||||||||||||
| CHROMOSOME | 1 | ||||||||||||||||
| HOMOLOGENE ID | 8022 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identifiedalpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental t |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. Association of diabetic nephropathy (DN) with the deletion of GSTT1 and GSTM1 genes is well reported. | 20521623 |
| Retinopathy | 1. The indicated that there was significant relationship between GSTM1 null genotype with retinopathy side effect of diabetes type 2. | 24355557 |
| Atherosclerosis | 1. The GSTT1-0 genotype and GSTT1-0/GSTM1-0 haplotype might be a potential determinants of susceptibility to advanced atherosclerosis in patients with type 2 diabetes mellitus. | 22330623 |