GSTT1
LOCUS ID2952
GENE_SYMBOLGSTT1
GENE NAMEglutathione S-transferase theta 1
SYNONYMNSNA
CHROMOSOME22
HOMOLOGENE IDNA
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene, glutathione S-transferase (GST) theta 1 (GSTT1), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT1 and GSTT2/GSTT2B share 55% amino acid sequence identity and may play a role in human carcinogenesis. The GSTT1 gene is haplotype-specific and is absent from 38% of the population. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2015]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Association of diabetic nephropathy (DN) with the deletion of GSTT1 and GSTM1 genes is well reported.20521623
Cardiovascular1. Genetic absence of the GSTT1 enzyme is an independent and powerful predictor of premature vascular morbidity and death in individuals with type 2 diabetes15927971
Retinopathy1. We may conclude that individuals homozygous for the deletion of GSTT1 are at an 2-fold-greater risk of diabetic retinopathy (DR), whereas the GSTM1 deficiency is associated with lower frequency of DR in type 2 diabetics.22377702
Atherosclerosis1. The GSTT1-0 genotype and GSTT1-0/GSTM1-0 haplotype might be a potential determints of susceptibility to advanced atherosclerosis in patients with type 2 diabetes mellitus.22330623