| GZMB |
| LOCUS ID | 3002 | ||||||||||
| GENE_SYMBOL | GZMB | ||||||||||
| GENE NAME | granzyme B | ||||||||||
| SYNONYMNS | C11, HLP, CCPI, CGL1, CSPB, SECT, CGL-1, CSP-B, CTLA1, CTSGL1 | ||||||||||
| CHROMOSOME | 14 | ||||||||||
| HOMOLOGENE ID | 108184 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Tuberculosis | 1. CD8(+) T cells were associated with significantly diminished expression of the cytotoxic markers perforin, granzyme B and CD107a both at baseline and following antigen or anti-CD3 stimulation, while NK cells were associated with significantly decreased antigen-stimulated expression of CD107a only. | 25363329 |