HDAC9
LOCUS ID9734
GENE_SYMBOLHDAC9
GENE NAMEhistone deacetylase
SYNONYMNSHD7 HD9 HD7b HDAC HDRP MITR HDAC7 HDAC7B HDAC9B HDAC9FL
CHROMOSOME7
HOMOLOGENE ID128578
microRNAsNANA
GENE SUMMARY
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of m

OBSERVATIONS

Complication Evidence PMID
Atherosclerosis1. Subgroup and multifactor dimensionality reduction analyses (MDR) further found the gene-environment interactions among SNP rs2107595, body mass index, type 2 diabetes and hyperlipidemia in CAD risk and the severity of coronary atherosclerosis. Our data suggest that SNP rs2107595 may contribute to coronary atherosclerosis and CAD risk through a possible mechanism of regulating HDAC9 expression and gene-environment interactions.27494404