| HGF |
| LOCUS ID | 3082 | |||||||||||||||||||
| GENE_SYMBOL | HGF | |||||||||||||||||||
| GENE NAME | hepatocyte growth factor (hepapoietin A; scatter factor) | |||||||||||||||||||
| SYNONYMNS | SF, HGFB, HPTA, F-TCF, DFNB39 | |||||||||||||||||||
| CHROMOSOME | 7 | |||||||||||||||||||
| HOMOLOGENE ID | 503 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1.expression of HGF inhibited renal expression of TGF-beta1 and reduced urine level of TGF-beta1 protein. Therefore, despite the effects of HGF on diabetic nephropathy being controversial, these observations suggest that supplementation of HGF is beneficial in ameliorating diabetic renal insufficiency in mice. | 15466268 |
| Atherosclerosis | 1. Serum HGF concentration may be a new marker of atherosclerotic complications in patients with Type 2 DM. | 16759302 |
| Neuropathy | 1. Nonviral gene transfer of human hepatocyte growth factor improves streptozotocin-induced diabetic neuropathy in rats. | 15734864 |
| Dyslipidemia | 1. This study shows decreased serum anti-inflammatory miR-146a, increased pro-inflammatory IL-8 and increased HGF (a vascular/insular repair factor) as discriminating markers of failure of glucose control occurring on the background of obesity and dyslipidemia. | 25500583 |