| HIF1A |
| LOCUS ID | 3091 | |||||||||||||
| GENE_SYMBOL | HIF1A | |||||||||||||
| GENE NAME | hypoxia inducible fa | |||||||||||||
| SYNONYMNS | HIF1, MOP1, PASD8, HIF-1A, bHLHe78, HIF-1alpha, HIF1-ALPHA, HIF-1-alpha | |||||||||||||
| CHROMOSOME | 14 | |||||||||||||
| HOMOLOGENE ID | 1171 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. The current study demonstrates for the first time that HIF1A Pro582Ser polymorphism has an effect on DN, possibly by conferring a relative resistance to the repressive effect of glucose on HIF-1A. | 22991450 |
| Insulin resistance and inflammation | 1. Using a transgenic model of overexpression of a constitutively active form of HIF1alpha, we determined that HIF1alpha fails to induce the expected proangiogenic response. | 19546236 |