HK2
LOCUS ID3099
GENE_SYMBOLHK2
GENE NAMEhexokinase 2
SYNONYMNSHKII, HXK2
CHROMOSOME2
HOMOLOGENE ID37273
microRNAsNANA
GENE SUMMARY
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells. [provided by RefSeq, Apr 2009]

OBSERVATIONS

Complication Evidence PMID
Tuberculosis1. Two genes, HK2 and CD28, emerged as potential culprits in diabetes-increased TB susceptibility.22230325