HMGA2
LOCUS ID8091
GENE_SYMBOLHMGA2
GENE NAMEhigh mobility group
SYNONYMNSBABL, LIPO, HMGIC, HMGI-C, STQTL9
CHROMOSOME12
HOMOLOGENE ID136767
microRNAsNANA
GENE SUMMARY
This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural D-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation.

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. These data demonstrate that the HMGA2 variant seems to be associated with increased risk of developing nephropathy in patients with type 2 diabetes and lower eGFR in both diabetic and non-diabetic individuals and could thus be a common denominator in the pathogenesis of type 2 diabetes and kidney complications.23111731