HMGA2
LOCUS ID8091
GENE_SYMBOLHMGA2
GENE NAMEhigh mobility group AT-hook 2
SYNONYMNSBABL, LIPO, HMGIC, HMGI-C, STQTL9
CHROMOSOME12
HOMOLOGENE ID136767
microRNAsNANA
GENE SUMMARY
This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural D-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alterte transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. These data demonstrate that the HMGA2 variant seems to be associated with increased risk of developing nephropathy in patients with type 2 diabetes and lower eGFR in both diabetic and non-diabetic individuals and could thus be a common denominator in the pathogenesis of type 2 diabetes and kidney complications.23111731