HRH1
LOCUS ID3269
GENE_SYMBOLHRH1
GENE NAMEhistamine receptor H1
SYNONYMNSH1R, H1-R, HH1R, hisH1
CHROMOSOME3
HOMOLOGENE ID668
microRNAsNANA
GENE SUMMARY
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of termil venules, the release of catecholamine from adrel medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pathophysiology of allergic diseases such as atopic dermatitis, asthma, aphylaxis and allergic rhinitis. Multiple altertively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2015]

OBSERVATIONS

Complication Evidence PMID
Neuropathy1.combination H1 and H2 receptor antagonist therapy in diabetic autonomic neuropathy.6123154