HRH2
LOCUS ID3274
GENE_SYMBOLHRH2
GENE NAMEhistamine receptor H2
SYNONYMNSH2R
CHROMOSOME5
HOMOLOGENE ID40613
microRNAsNANA
GENE SUMMARY
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestil motility and intestil secretion and is thought to be involved in regulating cell growth and differentiation. Altertively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

OBSERVATIONS

Complication Evidence PMID
Neuropathy1.combination H1 and H2 receptor antagonist therapy in diabetic autonomic neuropathy.6123154