| HRH2 |
| LOCUS ID | 3274 | ||||||||||
| GENE_SYMBOL | HRH2 | ||||||||||
| GENE NAME | histamine receptor H | ||||||||||
| SYNONYMNS | H2R | ||||||||||
| CHROMOSOME | 5 | ||||||||||
| HOMOLOGENE ID | 40613 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestil motility and intestil secretion and is thought to be involved in regulating cell growth and differentiation. Altertively splice |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Neuropathy | 1.combination H1 and H2 receptor antagonist therapy in diabetic autonomic neuropathy. | 6123154 |