HS6ST3
LOCUS ID266722
GENE_SYMBOLHS6ST3
GENE NAMEheparan sulfate 6-O-sulfotransferase 3
SYNONYMNS
CHROMOSOME13
HOMOLOGENE ID89201
microRNAsNANA
GENE SUMMARY
Heparan sulfate (HS) sulfotransferases, such as HS6ST3, modify HS to generate structures required for interactions between HS and a variety of proteins. These interactions are implicated in proliferation and differentiation, adhesion, migration, inflammation, blood coagulation, and other diverse processes (Habuchi et al., 2000 [PubMed 10644753]).[supplied by OMIM, Mar 2008]

OBSERVATIONS

Complication Evidence PMID
Retinopathy1. The heparan sulfate 6-O-sulfotransferase 3 (HS6ST3) gene is involved in heparan sulphate and heparin metabolism, and has been reported to be associated with diabetic retinopathy in type 2 diabetes24371161