HSPB1
LOCUS ID3315
GENE_SYMBOLHSPB1
GENE NAMEheat shock 27kDa protein 1
SYNONYMNSCMT2F, HMN2B, HSP27, HSP28, Hsp25, SRP27, HS.76067
CHROMOSOME7
HOMOLOGENE ID1180
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is induced by environmental stress and developmental changes. The encoded protein is involved in stress resistance and actin organization and translocates from the cytoplasm to the nucleus upon stress induction. Defects in this gene are a cause of Charcot-Marie-Tooth disease type 2F (CMT2F) and distal hereditary motor neuropathy (dHMN). [provided by RefSeq, Oct 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. both high glucose and Ang II contribute to HSPB1 upregulation. HSPB1 upregulation allows podocytes to better withstand an adverse high-glucose or Ang II-rich environment, such as can be found in DN.21931298