HSPG2
LOCUS ID3339
GENE_SYMBOLHSPG2
GENE NAMEheparan sulfate prot
SYNONYMNSPLC, SJA, SJS, HSPG, SJS1, PRCAN
CHROMOSOME1
HOMOLOGENE ID68473
microRNAsNANA
GENE SUMMARY
This gene encodes the perlecan protein, which consists of a core protein to which three long chains of glycosaminoglycans (heparan sulfate or chondroitin sulfate) are attached. The perlecan protein is a large multidomain proteoglycan that binds to and cross-links many extracellular matrix components and cell-surface molecules. It has been shown that this protein interacts with laminin, prolargin, collagen type IV, FGFBP1, FBLN2, FGF7 and transthyretin, etc., and it plays essential roles in multi

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Variants in or near ACE, AKR1B1 (two variants), APOC1, APOE, EPO, NOS3 (two variants), HSPG2, VEGFA, FRMD3 (two variants), CARS (two variants), CPVL and CHN2, UNC13B and GREM1, as well as four variants not near known genes, were associated with diabetic nephropathy.21127830