HTR2A
LOCUS ID3356
GENE_SYMBOLHTR2A
GENE NAME5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
SYNONYMNSHTR2, 5-HT2A
CHROMOSOME13
HOMOLOGENE ID68473
microRNAsNANA
GENE SUMMARY
This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Since recent reports have demonstrated the presence of 5-HT2A receptor in glomerular mesangial cells, it is possible that 5-HT may be involved in the development of diabetic nephropathy through the 5-HT2A receptor in mesangial cells.9767524