ID1
LOCUS ID3397
GENE_SYMBOLID1
GENE NAMEinhibitor of D binding 1, domint negative helix-loop-helix protein
SYNONYMNSID, bHLHb24
CHROMOSOME20
HOMOLOGENE ID168
microRNAsmiR-26a26776318
GENE SUMMARY
The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no D binding activity and therefore can inhibit the D binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. These data suggest that Scx and Id1 are involved in the BMP4-Smad1-SMA signal transduction pathway besides the TGFBeta1-Smad1-SMA signaling pathway and modulate phenotypic changes in MCs in diabetic nephropathy.22474292