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IFNG |
LOCUS ID | 3458 | ||||||||||||||||
GENE_SYMBOL | IFNG | ||||||||||||||||
GENE NAME | interferon, gamma | ||||||||||||||||
SYNONYMNS | IFG, IFI | ||||||||||||||||
CHROMOSOME | 12 | ||||||||||||||||
HOMOLOGENE ID | 1631 |
microRNAs | NA | NA |
GENE SUMMARY |
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This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015] |
OBSERVATIONS |
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Complication | Evidence | PMID |
Nephropathy | 1. IFNgamma and IL-10 were significantly elevated in patients with diabetic nephropathy (DN) and end-stage renal disease (ESRD) compared with controls and diabetic patients without DN. | 20187532 |
Neuropathy | 1. Our findings indicate that the tested markers within the IFNgamma and IL-10 genes, but not the TNFalpha gene, are significantly associated with peripheral neuropathy in South Indian type 2 diabetic patients. The study shows that the 'high-producer' IL-10 -1082 G/G genotype and the 'low-producer' IFNgamma +874 A/A genotype may be responsible for the down regulation of immune response leading to inflammation in this setting | 19608431 |
Tuberculosis | 1. Diabetes patients without tuberculosis, however, showed strongly reduced non-specific IFNgamma production, which is essential for inhibition of the initial growth of M. tuberculosis. Our data suggest that a defective non-specific immune response in diabetes may contribute to an increased susceptibility to develop tuberculosis. | 17962984 |