IGF1
LOCUS ID3479
GENE_SYMBOLIGF1
GENE NAMEinsulin-like growth factor 1 (somatomedin C)
SYNONYMNSMGF, IGFI, IGF-I
CHROMOSOME12
HOMOLOGENE ID55526
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Imbalances in the IGF-I system are associated with the development of diabetic nephropathy.16430721
Cardiovascular1. Evidence is accumulating that the promoter region of the insulin-like growth factor I (IGF-I) gene polymorphism and low levels of IGF-I are associated with type 2 diabetes, cardiovascular disease and birth weight17377412
Retinopathy1. In , our findings suggest that this IGF-I gene polymorphism is associated with an increased risk of diabetic retinopathy.16873705
Neuropathy1. Dysfunctional insulin and insulin-like growth factor-I (IGF-I) signaling contributes to the pathological progression of diabetes, diabetic peripheral neuropathy (DPN), Alzheimer's (AD), Parkinson's (PD) and Huntington's diseases (HD).22172248