Go to Advanced Search
IGF1 |
LOCUS ID | 3479 | |||||||||||||||||||
GENE_SYMBOL | IGF1 | |||||||||||||||||||
GENE NAME | insulin-like growth factor 1 (somatomedin C) | |||||||||||||||||||
SYNONYMNS | MGF, IGFI, IGF-I | |||||||||||||||||||
CHROMOSOME | 12 | |||||||||||||||||||
HOMOLOGENE ID | 55526 |
microRNAs | NA | NA |
GENE SUMMARY |
---|
The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015] |
OBSERVATIONS |
---|
Complication | Evidence | PMID |
Nephropathy | 1. Imbalances in the IGF-I system are associated with the development of diabetic nephropathy. | 16430721 |
Cardiovascular | 1. Evidence is accumulating that the promoter region of the insulin-like growth factor I (IGF-I) gene polymorphism and low levels of IGF-I are associated with type 2 diabetes, cardiovascular disease and birth weight | 17377412 |
Retinopathy | 1. In , our findings suggest that this IGF-I gene polymorphism is associated with an increased risk of diabetic retinopathy. | 16873705 |
Neuropathy | 1. Dysfunctional insulin and insulin-like growth factor-I (IGF-I) signaling contributes to the pathological progression of diabetes, diabetic peripheral neuropathy (DPN), Alzheimer's (AD), Parkinson's (PD) and Huntington's diseases (HD). | 22172248 |