IL12B
LOCUS ID3593
GENE_SYMBOLIL12B
GENE NAMEinterleukin 12B
SYNONYMNSCLMF NKSF CLMF2 IMD28 IMD29 NKSF2 IL-12B
CHROMOSOME5
HOMOLOGENE ID10400
microRNAsNANA
GENE SUMMARY
This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.

OBSERVATIONS

Complication Evidence PMID
Psoriasis1. In our population, genetic variation at IL12B, IL23R and IL23A has an influence not only on the risk for Ps but also on disease severity and type 2 diabetes mellitus.24957500