IL18
LOCUS ID3606
GENE_SYMBOLIL18
GENE NAMEinterleukin 18
SYNONYMNSIGIF, IL-18, IL-1g, IL1F4
CHROMOSOME11
HOMOLOGENE ID1200
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Upregulated IL-18 expression in type 2 diabetic subjects with nephropathyTGF-beta1 enhanced IL-18 expression in human renal proximal tubular epithelial cells.19110334
Cardiovascular1. The reduction in serum IL-18 levels across increasing numbers of +183 G-alleles was especially apparent in patient with diabetes type 2 and metabolic syndrome, suggesting a beneficial GG genotype in relation to cardiovascular outcome in these patients.22141572
Retinopathy1. In our previous studies, close relationship between proangiogenic activity of sera from type 2 diabetes mellitus patients (DM2) with background retinopathy, assessed in the in vivo serum-induced mouse cutaneous test (SIA), and VEGF and IL-18 serum concentration were observed.16204777
AtherosclerosisSerum levels of IL-18 might be a predictor of progression of diabetic nephropathy as well as cardiovascular diseases.16306550
Tuberculosis1. Tuberculosis with diabetes is characterized by elevated circulating levels of type 1 (IFN-?, tumor necrosis factor-?, and IL-2), type 2 (IL-5), and type 17 (IL-17A) cytokines but decreased circulating levels of IL-22. This was associated with increased systemic levels of other pro-inflammatory cytokines (IL-1?, IL-6, and IL-18) and an anti-inflammatory cytokine (IL-10) but not type 1 IFNs.23987505