| IL2 |
| LOCUS ID | 3558 | ||||||||||
| GENE_SYMBOL | IL2 | ||||||||||
| GENE NAME | interleukin 2 | ||||||||||
| SYNONYMNS | IL-2, TCGF, lymphokine | ||||||||||
| CHROMOSOME | 4 | ||||||||||
| HOMOLOGENE ID | 488 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerati |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Tuberculosis | 1. We found that TB-DM is characterized by elevated frequencies of mycobacterial antigen-stimulated CD8(+) T cells expressing type 1 [interferon-gamma and interleukin-2 (IL-2)] and type 17 (IL-17F) cytokines | 24907382 |