IL2
LOCUS ID3558
GENE_SYMBOLIL2
GENE NAMEinterleukin 2
SYNONYMNSIL-2, TCGF, lymphokine
CHROMOSOME4
HOMOLOGENE ID488
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Tuberculosis1. We found that TB-DM is characterized by elevated frequencies of mycobacterial antigen-stimulated CD8(+) T cells expressing type 1 [interferon-gamma and interleukin-2 (IL-2)] and type 17 (IL-17F) cytokines24907382