| IL23A |
| LOCUS ID | 51561 | |||||||||||||
| GENE_SYMBOL | IL23A | |||||||||||||
| GENE NAME | interleukin 23 | |||||||||||||
| SYNONYMNS | P19 SGRF IL-23 IL-23A IL23P19 | |||||||||||||
| CHROMOSOME | 12 | |||||||||||||
| HOMOLOGENE ID | 79042 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Psoriasis | 1. In our population, genetic variation at IL12B, IL23R and IL23A has an influence not only on the risk for Ps but also on disease severity and type 2 diabetes mellitus. | 24957500 |
| Retinopathy | 1. Electronic validation and diagnostic value analysis of the identified DEGs [cytokine inducible SH2 containing protein (CISH), SR?related CTD associated factor 11 (SCAF11), estrogen receptor 1 (ESR1), Rho GTPase activating protein 25 (ARHGAP25), major histocompatibility complex, class II, DR ?4 (HLA?DRB4) and interleukin 23 subunit ? (IL23A)] was performed in the GEO dataset. | 30942443 |