IL23A
LOCUS ID51561
GENE_SYMBOLIL23A
GENE NAMEinterleukin 23
SYNONYMNSP19 SGRF IL-23 IL-23A IL23P19
CHROMOSOME12
HOMOLOGENE ID79042
microRNAsNANA
GENE SUMMARY
This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells.

OBSERVATIONS

Complication Evidence PMID
Psoriasis1. In our population, genetic variation at IL12B, IL23R and IL23A has an influence not only on the risk for Ps but also on disease severity and type 2 diabetes mellitus.24957500