IL23R
LOCUS ID149233
GENE_SYMBOLIL23R
GENE NAMEinterleukin 23 receptor
SYNONYMNS
CHROMOSOME1
HOMOLOGENE ID87555
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner.

OBSERVATIONS

Complication Evidence PMID
Psoriasis1. In our population, genetic variation at IL12B, IL23R and IL23A has an influence not only on the risk for Ps but also on disease severity and type 2 diabetes mellitus.24957500