IRAK1
LOCUS ID3654
GENE_SYMBOLIRAK1
GENE NAMEinterleukin 1 receptor associated kinase 1
SYNONYMNSIRAK, pelle
CHROMOSOMEX
HOMOLOGENE ID37496
microRNAsNANA
GENE SUMMARY
This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Altertively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Neuropathy1. Treatment of diabetic peripheral neuropathy with sildefil, a phosphodiesterase type 5 inhibitor, augmentedMiRNA-146a expression and decreased levels of IRAK1 and TRAF6 in the DRG neurons. In vitro, blockage ofMiRNA-146a in DRG neurons abolished the effect of sildefil on DRG neuron protection and downregulation of IRAK1 and TRAF6 proteins under hyperglycemia. Our data provide the first evidence showing thatMiRNA-146a plays an important role in mediating DRG neuron apoptosis under hyperglycemic conditions.24316060