| IRAK4 |
| LOCUS ID | 51135 | ||||||||||
| GENE_SYMBOL | IRAK4 | ||||||||||
| GENE NAME | interleukin 1 recept | ||||||||||
| SYNONYMNS | IPD1,REN64,IRAK-4,NY-REN-64 | ||||||||||
| CHROMOSOME | 12 | ||||||||||
| HOMOLOGENE ID | 41109 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Atherosclerosis | 1.The activation of IRAK4 phenotypically modulated VSMCs from differentiation to dedifferentiation. Inactivation of IRAK4 exerts a protective effect on VSMCs differentiation and inhibits inflammation. IRAK4 could therefore be a target for interventions to prevent and treat the initial phase of atherosclerosis. | 27158377 |