IRS1
LOCUS ID3667
GENE_SYMBOLIRS1
GENE NAMEinsulin receptor substrate 1
SYNONYMNSHIRS-1
CHROMOSOME2
HOMOLOGENE ID4049
microRNAsmiR-14424497980
GENE SUMMARY
This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009]

OBSERVATIONS

Complication Evidence PMID
Retinopathy1. The goal of this present study was to investigate a potential mechanism for retinal endothelial cell apoptosis in response to hyperglycemia.Increased TNF-alpha inhibits insulin signaling in 2 ways1) increased phosphorylation of IRS-1(Ser307), 2) increased SOCS3 levels to decrease total IRS-1 and increase IR(Tyr960), both of which block normal insulin signal transduction.22266116