ITGA2
LOCUS ID3673
GENE_SYMBOLITGA2
GENE NAMEintegrin subunit alpha 2
SYNONYMNSBR, GPIa, CD49B, HPA-5, VLA-2, VLAA2
CHROMOSOME5
HOMOLOGENE ID1662
microRNAsNANA
GENE SUMMARY
This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neotal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Altertive splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

OBSERVATIONS

Complication Evidence PMID
Retinopathy1. A significant association between the G894T polymorphism of eNOS and BgI II polymorphism of ITGA2 genes and DR was observed23776381