ITGAM
LOCUS ID3684
GENE_SYMBOLITGAM
GENE NAMEintegrin, alpha M (complement component 3 receptor 3 subunit)
SYNONYMNSCR3A, MO1A, CD11B, MAC-1, MAC1A, SLEB6
CHROMOSOME16
HOMOLOGENE ID526
microRNAsNANA
GENE SUMMARY
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. The expression of the CD11b antigen on the surface of the polymorphonuclear leukocytes is increased in patients with early diabetic nephropathy (microangiopathy) and diabetic patients before development vascular complications, suggesting the presence of an increased inflammatory response in these individuals.16617732
Retinopathy1. We conclude that antagonism of CD11b (integrin alphambeta2) by NIF is sufficient to inhibit early stages of diabetic retinopathy, while not compromising the basic immune response.24205223