ITGB3
LOCUS ID3690
GENE_SYMBOLITGB3
GENE NAMEintegrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
SYNONYMNSGT, CD61, GP3A, BDPLT2, GPIIIa, BDPLT16
CHROMOSOME17
HOMOLOGENE ID55444
microRNAsNANA
GENE SUMMARY
The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated siglling. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Retinopathy1. Genetic polymorphisms of the alpha2beta1 integrin and glycoprotein IIIa (GPIIIa) have been associated with myocardial infarction, stroke, and diabetic retinopathy.11728949