JAZF1
LOCUS ID221895
GENE_SYMBOLJAZF1
GENE NAMEJAZF zinc finger 1
SYNONYMNSTIP27, ZNF802
CHROMOSOME7
HOMOLOGENE ID18291
microRNAsNANA
GENE SUMMARY
This gene encodes a nuclear protein with three C2H2-type zinc fingers, and functions as a transcriptional repressor. Chromosomal aberrations involving this gene are associated with endometrial stromal tumors. Altertively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. After adjusting for age, gender and body mass index, genetic variants JAZF1 rs864745, FTO rs8050136, and HHEX/IDE rs5015480 were significantly related to reduced estimated glomerular filtration rate (P < 0.05).JAZF1, FTO, CDKAL1, and HHEX/IDE are associated with diabetic nephropahy23298195
Cardiovascular1. WFS1, CDKN2A/B, CDC123/CAMK1D, JAZF1, FTO, CDKAL1, and HHEX/IDE are associated with cardiovascular risk.23298195