KLF6
LOCUS ID1316
GENE_SYMBOLKLF6
GENE NAMEKruppel-like factor 6
SYNONYMNSGBF, ZF9, BCD1, CBA1, CPBP, PAC1, ST12, COPEB
CHROMOSOME10
HOMOLOGENE ID996
microRNAsNANA
GENE SUMMARY
This gene encodes a member of the Kruppel-like family of transcription factors. The zinc finger protein is a transcriptional activator, and functions as a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene, some of which are implicated in carcinogenesis. [provided by RefSeq, May 2009]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. KLF6 overexpression increased MIP-3alpha which was inhibited by concurrent exposure to PPAR-gamma agonists. PPAR-gamma agonists attenuated high glucose-induced MIP-3alpha secretion.The recognition of MIP-3alpha as a significant pathogenic mediator in diabetic nephropathy reaffirms the increasingly recognized role of inflammation in the progression of DN21109018