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KLF6 |
LOCUS ID | 1316 | ||||||||||
GENE_SYMBOL | KLF6 | ||||||||||
GENE NAME | Kruppel-like factor 6 | ||||||||||
SYNONYMNS | GBF, ZF9, BCD1, CBA1, CPBP, PAC1, ST12, COPEB | ||||||||||
CHROMOSOME | 10 | ||||||||||
HOMOLOGENE ID | 996 |
microRNAs | NA | NA |
GENE SUMMARY |
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This gene encodes a member of the Kruppel-like family of transcription factors. The zinc finger protein is a transcriptional activator, and functions as a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene, some of which are implicated in carcinogenesis. [provided by RefSeq, May 2009] |
OBSERVATIONS |
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Complication | Evidence | PMID |
Nephropathy | 1. KLF6 overexpression increased MIP-3alpha which was inhibited by concurrent exposure to PPAR-gamma agonists. PPAR-gamma agonists attenuated high glucose-induced MIP-3alpha secretion.The recognition of MIP-3alpha as a significant pathogenic mediator in diabetic nephropathy reaffirms the increasingly recognized role of inflammation in the progression of DN | 21109018 |