LPL
LOCUS ID4023
GENE_SYMBOLLPL
GENE NAMElipoprotein lipase
SYNONYMNSLIPD, HDLCQ11
CHROMOSOME8
HOMOLOGENE ID200
microRNAsNANA
GENE SUMMARY
LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. The LPL mass was inversely associated with Von Willebrand factor (vWF), suggesting that widespread endothelial cell damage in a reduction in LPL bound to endothelium in diabetic subjects with microalbuminuria.plasma lipoprotein profiles become more atherogenic in patients with diabetic nephropathy, including the subclinical stage, compared with diabetics without nephropathy or those with nondiabetic kidney disease.10412730
Cardiovascular1. Polymorphisms in LPL, CETP, and HL Protect HIV-Infected Patients from Atherogenic Dyslipidemia in an Allele-Dose-Dependent Manner.26101956
Atherosclerosis1. Dysregulation of macrophage PPARs in the arterial wall may contribute, by increasing the in vivo macrophage production of LPL and of proinflammatory cytokines, to the accelerated atherosclerosis associated with diabetes.10634806
Neuropathy1. These show that streptozotocin (STZ) -induced diabetes causes a decrease in LPL activity in the sciatic nerve that, as in other tissues, is reversible with insulin treatment. These data may suggest a role for LPL in the pathophysiology of diabetic neuropathy.11897675