| LRG1 |
| LOCUS ID | 116844 | ||||||||||
| GENE_SYMBOL | LRG1 | ||||||||||
| GENE NAME | leucine rich alpha-2 | ||||||||||
| SYNONYMNS | LRG, HMFT1766 | ||||||||||
| CHROMOSOME | 19 | ||||||||||
| HOMOLOGENE ID | 36468 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The leucine-rich repeat (LRR) family of proteins, including LRG1, have been shown to be involved in protein-protein interaction, signal transduction, and cell adhesion and development. LRG1 is expressed during granulocyte differentiation |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Retinopathy | 1. A total of 86 plasma and 33 vitreous samples were collected and subjected to enzyme-linked immunosorbent assay. The diagnostic value of plasma LRG1 was tested using receiver operating characteristic (ROC) curves.RESULTS: Plasma LRG1 in PDR patients (9025 ? 1870 pg/ml) was significantly increased as compared with controls (5975 ? 2022 pg/ml), T2DM without DR (6550 ? 2359 pg/ml) and NPDR patients (6550 ? 2359 pg/ml) (p < 0.0001).KEYWORDS: biomarkers; diabetic retinopathy; leucine-rich-?2-glycoprotein; therapeutic target. 2. Baseline PWV mediated 12.0% of the association between LRG1 and PDR (p?=?0.03). CONCLUSION: Baseline plasma LRG1 is associated with PDR, suggesting it maybe a promising biomarker for prediction for advanced proliferative stages of DR. | 29168314 |